124012  Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2

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23 April 2014

Product number Qty/Pk Quantity Price
124012-10MG  10 mg  loading
124012-1MG  1 mg  loading
Prices are subject to change without notice.
A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038).
Product information
Form Solid
Primary Target Akt1,Akt 2, Akt3
Molar mass 320.3
Protect from Light Yes
Packaged under inert gas Yes
Cell permeable Yes
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C13H16N6O4
RTECS RY8455000
CAS number 35943-35-2
Store and ship information
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Carcinogenic / Teratogenic
Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem, molecular structure

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