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31 May 2012
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Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM).
| Product information | |||
|---|---|---|---|
| Peptide Sequence | H-Ile-Val-Cys3-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹6-Pro-Pro-Gly-Glu-Asn-Leu-Cys23-Tyr-Arg-Lys-Met-Trp-Cys29-Asp-Ala-Phe-Cys33-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys44-Ala-Ala-Thr-Cys48-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys59-Cys60-Ser-Thr-Asp-Lys-Cys65-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65) | ||
| Form | Lyophilized solid | ||
| Molar mass | 7984.3 | ||
| Contaminants | None detectable by IEF. Supplied as an acetate salt | ||
| Solubility | H2O or PBS | ||
| Chemical formula | C338H529N97O105S11 | ||
| RTECS | EI6201400 | ||
| CAS number | 11032-79-4 | ||
| Merck USA index | 14, 1488 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Harmful |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 36 Wear suitable protective clothing. |
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| R Phrase |
R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
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