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Merck KGaA
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31 May 2012
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A cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 µM for Jurkat, Molt-4, and CCRF-CEM) and shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1.
| Product information | |||
|---|---|---|---|
| Form | Orange solid | ||
| Molar mass | 306.1 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO or MeOH | ||
| Chemical formula | C15H9Cl2NO2 | ||
| CAS number | 79183-19-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
