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31 May 2012
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A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Binds to aFGF and reduces its angiogenic activity. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is a potent inhibitor of DNA topoisomerase II (IC50= 75 nM for the yeast enzyme as measured by relaxation assays) that also acts as a potent inhibitor of angiogenesis. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cγ. Inhibits both major calpain isoforms (IC50 = 22 µM and IC50 = 10 µM for µ-calpain and m-calpain, respectively).
Dye content: ~85%.
| Product information | |||
|---|---|---|---|
| Form | Red solid | ||
| Primary Target | DNA topoisomerase 2 | ||
| Primary Target IC50 | 75 nM | ||
| Secondary target | IC50 = 22 µM and IC50 = 10 µM for µ-calpain and m-calpain, respectively | ||
| Molar mass | 422.4 | ||
| Cell permeable | Yes | ||
| Solubility | 0.1M NaOH | ||
| Chemical formula | C22H14O9 | ||
| RTECS | GU4790000 | ||
| CAS number | 4431-00-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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