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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
31 Mai 2012
wird geladen
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP).
Note: 1 set = 3 x 10 µg
| Produktinformationen | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | vacuolar type H+ ATPase | ||
| Primary Target IC50 | 500 pM | ||
| Protect from Light | Ja | ||
| Purity | ≥90% by HPLC | ||
| Chemische Formel | C35H58O9 | ||
| CAS-Nummer | 88899-55-2 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
||
| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 22-26-36 |
||
| R-Satz |
R: 36/37/38 |
||
