Para preguntas en general por favor contacte a nuestro Servicio de Atención al Cliente:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Teléfono: +49 6151 72-0
Fax: +49 6151 72 2000
31 mayo 2012
cargando
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP).
Note: 1 set = 3 x 10 µg
| Información sobre producto | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | vacuolar type H+ ATPase | ||
| Primary Target IC50 | 500 pM | ||
| Protect from Light | Si | ||
| Purity | ≥90% by HPLC | ||
| Fórmula químico | C35H58O9 | ||
| Número CAS | 88899-55-2 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | -20°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
||
| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 22-26-36 |
||
| Frase R |
R: 36/37/38 |
||
