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Merck KGaA
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64293 Darmstadt
Germany
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Fax: +49 6151 72 2000
31 May 2012
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A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. Excellent insulin mimetic at 15 µg/kg in vitro and in vivo for use. Inhibits the in situ dephosphorylation of autophosphorylated insulin receptors with over 1000-fold greater potency than sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G2/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC50 = 38 nM).
The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Primary Target | PTEN | ||
| Primary Target IC50 | 38 nM | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥99% by 5¹V-NMR | ||
| Solubility | H2O | ||
| Chemical formula | K[VO(O2)2C12H8N2] | ||
| CAS number | 42494-73-5 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
