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31 May 2012
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Specific calcineurin inhibitor. Corresponds to the C-terminal domain (residues 457-482) of the calmodulin-binding domain of calcineurin (PP2B). Inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 µM using 32P-myosin light chain as a substrate) but has no effect on Ni2+-stimulated enzyme activity. Does not inhibit CaM kinase II, protein phosphatase 1 or 2A.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | H-Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-OH | ||
| Form | Lyophilized | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Primary Target | Mn2+-stimulated calcineurin activity | ||
| Primary Target IC50 | 10 µM using 32P-myosin light chain as a substrate | ||
| Molar mass | 2930.4 | ||
| Hygrocopic | Yes | ||
| Purity | ≥97% by HPLC | ||
| Sold on the basis of peptide content | Yes | ||
| Solubility | H2O | ||
| Chemical formula | C124H205N39O39S2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
