390238
Camptothecin, 10-Hydroxy-, Camptotheca acuminata
10-Hydroxycamptothecin, HCPT
For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
loading
A cell-permeable powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
| Product information | |||
|---|---|---|---|
| Form | Pale yellow powder | ||
| Primary Target | DNA topoisomerase I | ||
| Secondary target | phosphorylation of histone H1 and H3 | ||
| Molar mass | 364.4 | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C20H16N2O5 | ||
| CAS number | 64439-81-2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
||
| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
||
| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
||
