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31 May 2012
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Native cathepsin B from human liver, purified by affinity chromatography. The most investigated enzyme of all lysosomal cysteine proteases. Upregulation and secretion of cathepsin B have been shown to occur in many types of tumors and to correlate positively with their invasive and metastatic capabilities. Cathepsin B is shown to facilitate tumor invasion by dissolving extracellular barriers.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | In 50 mM sodium acetate buffer, 1 mM EDTA, pH 5.0. | ||
| Molar mass | 27500 | ||
| Avoid freeze/thaw | Yes | ||
| Specific activity | ≥50 U/mg protein | ||
| Unit definition | One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-RR-βNA per min at 40°C, pH 6.0 in the presence of DTT. | ||
| Purity | >95% by SDS-PAGE | ||
| Source | Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. | ||
| pH value | optimum 3.5 - 6.0 | ||
| EC number | 3.4.22.1 | ||
| CAS number | 9047-22-7 | ||
| Merck USA index | 14, 1905 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Standard Handling |
||
