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31 May 2012
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Native cathepsin D from human liver. A major lysosomal aspartyl protease produced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and releases growth factors bound to the matrix.
| Product information | |||
|---|---|---|---|
| Form | Lyophilized | ||
| Formulation | Lyophilized from 2 mM sodium phosphate buffer, pH 6.5. | ||
| Molar mass | 42000 | ||
| Specific activity | ≥300 units/mg protein | ||
| Unit definition | One unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm | ||
| Purity | ≥90% by SDS-PAGE | ||
| Source | Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. | ||
| Solubility | Sterile H2O or Aqueous Buffers | ||
| EC number | 3.4.23.5 | ||
| CAS number | 9025-26-7 | ||
| Merck USA index | 14, 1905 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
