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31 May 2012
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Native cathepsin G from human neutrophil. A serine protease that degrades collagen and proteoglycans. Has been implicated in connective tissue diseases such as emphysema and rheumatoid arthritis. Acts as a potent agonist of human platelet activation leading to their aggregation. Reported to be involved in the activation of pro MMP-2 via mechanism requiring MT1-MMP. Inhibited by chymostatin, DFP, and Z-Phe-CH2Br. Reconstitute in 150 mM NaCl, 50 mM sodium acetate buffer, pH 5.5.
Note: 1 mU = 1 milliunit.
| Product information | |||
|---|---|---|---|
| Form | Salt-free lyophilized solid | ||
| Molar mass | 23500 | ||
| Specific activity | ≥2 units/mg protein | ||
| Unit definition | One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Suc-AAPF-pNA per min at 25°C, pH 7.5. | ||
| Purity | ≥95% by SDS-PAGE | ||
| Source | Prepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. | ||
| pH value | optimum 7.5 | ||
| Solubility | 100mM NaCl, 50 mM Sodium acetate, pH 5.5. | ||
| EC number | 3.4.21.20 | ||
| CAS number | 107200-92-0 | ||
| Merck USA index | 14, 1905 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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