227013
CCR4 Antagonist
2-(1,4′-Bipiperidine-1′-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine, C-021
For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
loading
A cell-permeable diaminoquinazoline compound that acts as a potent antagonist against the G-protein-coupled chemokine receptor CCR4 (IC50 = 73 and 18 nM against CCL22-binding and CCL22-induced GTPγS recruitment, respectively). Shown to inhibit CCL22/CCR4-mediated chemotaxis in both murine and human cultures (IC50 = 39 and 140 nM, respectively).
| Product information | |||
|---|---|---|---|
| Form | Light beige solid | ||
| Molar mass | 476.7 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C27H41N5O2 • 0.5 H2O | ||
| CAS number | 864289-85-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
