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31 May 2012
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Naturally-occurring alkaloid. Potent, selective, and cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain of PKC. A competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
| Product information | |||
|---|---|---|---|
| Form | Light yellow to yellow solid | ||
| Primary Target | PKC | ||
| Primary Target IC50 | 660 nM | ||
| Molar mass | 383.8 | ||
| Cell permeable | Yes | ||
| Purity | ≥97% by NMR | ||
| Solubility | DMSO or H2O | ||
| Chemical formula | C21H18NO4Cl | ||
| RTECS | FL9200000 | ||
| CAS number | 3895-92-9 | ||
| Merck USA index | 14, 2051 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Harmful |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 20/21/22-36/37/38 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. |
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