287840
Diclofenac Sodium
2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC50 = 9.5 µM).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | COX-1 | ||
| Primary Target IC50 | 60 nM | ||
| Secondary target | COX-2 (IC50 = 200 nM) | ||
| Molar mass | 318.1 | ||
| Hygrocopic | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by TLC | ||
| Solubility | H2O | ||
| Chemical formula | C14H10Cl2NO2 · Na | ||
| RTECS | AG6330000 | ||
| CAS number | 15307-79-6 | ||
| Merck USA index | 14, 3081 | ||
| Store and ship information | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Toxic & Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-36 Do not breathe dust. Wear suitable protective clothing. |
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| R Phrase |
R: 23/24/25-63 Toxic by inhalation, in contact with skin and if swallowed. Possible risk of harm to the unborn child. |
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