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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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Catalyzes ADP-ribosylation of eukaryotic aminoacyltransferase II (EF2) using NAD as substrate, thereby inhibiting protein synthesis. May also induce internucleosomal breakdown. Causes DNA fragmentation and cytolysis in U937 cells. Activation requires nicking with a protease followed by reduction with DTT.
| Product information | |||
|---|---|---|---|
| Form | Solid | ||
| Formulation | Lyophilized from sterile 10 mM Tris, 1 mM EDTA, pH 7.5. | ||
| Molar mass | 63000 | ||
| Purity | Major band (under reducing conditions) of ~63 kDa | ||
| Solubility | Aqueous Buffers or H2O | ||
| RTECS | XW5807200 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful |
||
| Canadian export regulations | Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada. | ||
| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 36 Wear suitable protective clothing. |
||
| R Phrase |
R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
||
