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Merck KGaA
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31 May 2012
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Antitumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, thereby inhibiting nucleic acid synthesis. Induces apoptosis in rhabdomyosarcoma cell lines.
| Product information | |||
|---|---|---|---|
| Form | Red solid | ||
| Primary Target | topoisomerase 2 | ||
| Primary Target IC50 | 100 nM | ||
| Molar mass | 580.0 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | H2O | ||
| Chemical formula | C27H29NO11 · HCl | ||
| RTECS | QI9295900 | ||
| CAS number | 25316-40-9 | ||
| Merck USA index | 14, 3439 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 36/37-45-53-22-28 Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use. Do not breathe dust. |
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| R Phrase |
R: 45-46 May cause cancer. May cause heritable genetic damage. |
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