324385
Doxycycline, Hyclate
α-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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A commonly-used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (interstitial collagenase; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.
| Product information | |||
|---|---|---|---|
| Form | Light yellow crystalline solid | ||
| Molar mass | 512.9 | ||
| Hygrocopic | Yes | ||
| Purity | ≥95% by TLC | ||
| Solubility | H2O | ||
| Chemical formula | C22H24N2O8 · HCl · 1/2(H2O) · 1/2(C2H6O) | ||
| RTECS | QI8925000 | ||
| CAS number | 24390-14-5 | ||
| Merck USA index | 14, 3440 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful & Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-36 Do not breathe dust. Wear suitable protective clothing. |
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| R Phrase |
R: 20/21/22-63 Harmful by inhalation, in contact with skin and if swallowed. Possible risk of harm to the unborn child. |
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