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01 June 2012
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A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC50 > 350 µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | EGFR kinase | ||
| Primary Target IC50 | 2.6 µM | ||
| Molar mass | 270.2 | ||
| Protect from Light | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C15H10O5 | ||
| RTECS | NR2392000 | ||
| CAS number | 446-72-0 | ||
| Merck USA index | 14, 4391 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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