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444937  MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv

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24 April 2014

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Product number Qty/Pk Quantity Price
444937-1MG  1 mg  loading
444937-5MG  5 mg  loading
Prices are subject to change without notice.
A cell-permeable pyridine-containing vinylogous cyanamide compound that acts as a potent and selective inhibitor of MEK (IC50 = 12 nM) with little activity towards MKK3 and MKK4 (IC50 > 1 µM). The inhibition is noncompetitive with respect to ERK and the compound displays significant affinity only towards ATP-bound MEK (i.e. noncompetitive with respect to ATP). Exhibits superior potency, solubility, and stability compared to U0126 (Cat. No. 662005) in aqueous solutions. Shown to protect against phorbol ester-mediated ear edema in mice (ED50 of 5 mg/kg, ip.).
Product information
Form White solid
Primary Target MEK
Primary Target IC50 12 nM
Secondary target MKK3 and MKK4 (IC50 > 1 µM)
Molar mass 374.5
Protect from Light Yes
Packaged under inert gas Yes
Cell permeable Yes
Purity ≥ 95% by HPLC (sum of two isomers)
Solubility DMSO or MeOH
Chemical formula C21H18N4OS
CAS number 297744-42-4
Store and ship information
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Standard Handling
MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014


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