For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
01 June 2012
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Recombinant, human MMP-13. MMP-13 is a collagenase-3 enzyme that degrades a range of extracellular matrix proteins, including collagen types I, II, III, IV, IX, X, and XIV, gelatin, aggrecan, perlecan and fibronectin. It is distinguished from other human collagenases by the fact that it effectively degrades type II collagen. The importance of MMP-13 is further strengthened by reports that it is a biomarker for poor prognosis in many carcinomas and other type of cancers.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | In 50 mM HEPES, 10 mM CaCl2, 20% glycerol, 0.005% BRIJ® 35 Detergent, pH 7.5. APMA-free. | ||
| Molar mass | 52000 | ||
| Avoid freeze/thaw | Yes | ||
| Specific activity | ≥50 mU/mg protein | ||
| Unit definition | One unit is defined as the amount of APMA-activated enzyme that will hydrolyze 1µmol MCA-Pro-Leu-Lys-Gly-Leu-DPA-Ala-Arg-NH2 (Cat. No. 03-32-5032) at 37°C, pH 7.5. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Standard Handling |
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