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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
01 Juni 2012
wird geladen
An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and protein phosphatase 2A (IC50 = 0.1 nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. A 250 µM (25 µg/124 µl) solution of Okadaic Acid, (Cat. No. 495609) in DMSO is also available.
| Alternativen | |
|---|---|
| 459618 | Okadaic Acid, Potassium Salt |
| 459616 | Okadaic Acid, Ammonium Salt |
| 459620 | Okadaic Acid, Sodium Salt |
| Alternative Produkte für Okadaic Acid, Prorocentrum sp. | |
| 459618 | Okadaic Acid, Potassium Salt |
| 459616 | Okadaic Acid, Ammonium Salt |
| 459620 | Okadaic Acid, Sodium Salt |
| Zubehör für Okadaic Acid, Prorocentrum sp. |
| Produktinformationen | |||
|---|---|---|---|
| Form | Colorless glassy solid | ||
| Primary Target | protein phosphatase | ||
| Primary Target IC50 | 10-15 nM | ||
| Secondary target | protein phosphatse 2A (IC50 = 0.1 nM) | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Purity | ≥95% by HPLC | ||
| Chemische Formel | C44H68O13 | ||
| RTECS | AA8227800 | ||
| CAS-Nummer | 78111-17-8 | ||
| Merck USA index | 14, 6819 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
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Achtung Gefahrgut:Aufgrund der Natur des in dieser Lieferung enthaltenen Gefahrgutes können zusätzliche Versandkosten für Ihren Auftrag entstehen. Bestimmte Größen können ggf. von den Versandzuschlägen für Gefahrgüter ausgenommen sein. Bitte kontaktieren Sie Ihr lokales Verkaufsbüro für weitere Informationen bzgl. dieser Gebühren. |
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| Lagerkategorie | -20°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 22-26-36/37/39-45 |
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| R-Satz |
R: 23/24/25-38 |
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