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Merck KGaA
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01 junio 2012
cargando
An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and protein phosphatase 2A (IC50 = 0.1 nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. A 250 µM (25 µg/124 µl) solution of Okadaic Acid, (Cat. No. 495609) in DMSO is also available.
| Producto alternativo | |
|---|---|
| 459618 | Okadaic Acid, Potassium Salt |
| 459616 | Okadaic Acid, Ammonium Salt |
| 459620 | Okadaic Acid, Sodium Salt |
| Productos alternativos para Okadaic Acid, Prorocentrum sp. | |
| 459618 | Okadaic Acid, Potassium Salt |
| 459616 | Okadaic Acid, Ammonium Salt |
| 459620 | Okadaic Acid, Sodium Salt |
| Accesorios para Okadaic Acid, Prorocentrum sp. |
| Información sobre producto | |||
|---|---|---|---|
| Form | Colorless glassy solid | ||
| Primary Target | protein phosphatase | ||
| Primary Target IC50 | 10-15 nM | ||
| Secondary target | protein phosphatse 2A (IC50 = 0.1 nM) | ||
| Protect from Light | Si | ||
| Packaged under inert gas | Si | ||
| Purity | ≥95% by HPLC | ||
| Fórmula químico | C44H68O13 | ||
| RTECS | AA8227800 | ||
| Número CAS | 78111-17-8 | ||
| Merck USA index | 14, 6819 | ||
| Almacenar y enviar información | |||
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Advertencia de materiales peligrosos: Debido a la naturaleza de los materiales peligrosos de este envío, podrían aplicarse gastos de envío añadidos a su pedido. Ciertos tamaños pueden estar exentos de los gastos de envío añadidos a los materiales peligrosos. Consulte a su oficina local de ventas si desea más información relativa a esos gastos. |
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| Categoría de alamacenamiento | -20°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 22-26-36/37/39-45 |
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| Frase R |
R: 23/24/25-38 |
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