528108  PI 3-Kγ Inhibitor II

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II

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20 April 2014

Product number Qty/Pk Quantity Price
528108-5MG  5 mg  loading
Prices are subject to change without notice.
A cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
Product information
Form Off-white solid
Primary Target PI 3-Kg
Primary Target IC50 250 nM
Primary Target Ki 180 nM
Secondary target PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM)
Molar mass 285.2
Protect from Light Yes
Packaged under inert gas Yes
Cell permeable Yes
ATP Competitive Yes
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C11H5F2NO4S
CAS number 648449-76-7
Store and ship information
Storage +2°C to +8°C
Ship Ambient Temperature Only
PI 3-Kγ Inhibitor II, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014


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