Information
X


528108  PI 3-Kγ Inhibitor II

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II

For general questions please contact our Customer Service:

Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000

Contact us


20 April 2014

loading
 
Product number Qty/Pk Quantity Price
528108-5MG  5 mg  loading
Prices are subject to change without notice.
A cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kγ (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
Product information
Form Off-white solid
Primary Target PI 3-Kg
Primary Target IC50 250 nM
Primary Target Ki 180 nM
Secondary target PI 3-Kα (IC50 = 4.5 µM), PI 3-Kβ and δ (IC50 > 20 µM)
Molar mass 285.2
Protect from Light Yes
Packaged under inert gas Yes
Cell permeable Yes
ATP Competitive Yes
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C11H5F2NO4S
CAS number 648449-76-7
Store and ship information
Storage +2°C to +8°C
Ship Ambient Temperature Only
Irritant
PI 3-Kγ Inhibitor II, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014


x

Welcome to Merck Millipore

 

Europe, Middle East and Africa Asia / Pacific North America, Central America and the Caribbean South America

Please choose your country:

North America, Central America and the Caribbean

South America

Europe, Middle East and Africa

Asia / Pacific

All countries from A to Z

If you can't find your country please click here.

 

Privacy Statement

 

x

Merck Chemicals Cart ()

You are entering the Millipore online shop. Both carts are maintained for you while you shop between sites. We recommend to complete your Merck order before visiting Millipore.com.

Go to Millipore Proceed to checkout


What kind of products are you looking for?

Millipore

Bio manufacturing and Life science.

Merck Chemicals

High-quality industrial and laboratory chemicals.


Important message


It is currently not possible to order Bioscience products together with other Merck products. We recommend completing your current order first.

Do you wish to proceed without completing your current order? If so, this will empty your shopping cart.