557401
RNA-Editing Ligase 1 Inhibitor, NSC 45208
4,5-Dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid, disodium salt, dihydrate, REL1 Inhibitor
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Merck KGaA
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01 Juni 2012
wird geladen
A sulfonated azo dye, initially identified by a Trypanosoma burcei RNA-editing ligase 1 (TbREL1) crystal structure-based inhibitor screening, is shown to inhibit TbREL1 activity (IC50 = 1.95 µM) by targeting the enzyme's ATP binding pocket. V1 is less potent against T4 phage RNA ligase 2 and human DNA ligase IIIβ (IC50 = 3.53 and 27.49 µM, respectively).
| Produktinformationen | |||
|---|---|---|---|
| Form | Dark red solid | ||
| Protect from Light | Ja | ||
| Hygrocopic | Ja | ||
| Packaged under inert gas | Ja | ||
| Purity | ≥95% based on elemental analysis | ||
| Chemische Formel | C20H12N2Na2O8S2 • 4H2O | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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