557514
Ro-31-8425
2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
22 May 2013
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A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε).
| Product information | |||
|---|---|---|---|
| Form | Reddish-orange solid | ||
| Primary Target | PKC | ||
| Primary Target IC50 | 15 nM | ||
| Secondary target | PKCα (IC50 = 8 nM), PKCβI (IC50 = 8 nM), PKCβII (IC50 = 14 nM) | ||
| Molar mass | 461.0 | ||
| Protect from Light | Yes | ||
| Purity | ≥94% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C26H24N4O2 · HCl | ||
| CAS number | 131848-97-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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