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557514  Ro-31-8425

2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl

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24 April 2014

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Product number Qty/Pk Quantity Price
557514-1MG  1 mg  loading
Prices are subject to change without notice.
A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε).
Product information
Form Reddish-orange solid
Primary Target PKC
Primary Target IC50 15 nM
Secondary target PKCα (IC50 = 8 nM), PKCβI (IC50 = 8 nM), PKCβII (IC50 = 14 nM)
Molar mass 461.0
Protect from Light Yes
Purity ≥94% by HPLC
Solubility DMSO
Chemical formula C26H24N4O2 · HCl
CAS number 131848-97-0
Store and ship information
Storage +2°C to +8°C
Ship Ambient Temperature Only
Irritant
Safety information
S Phrase S: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
R Phrase R: 36/37/38

Irritating to eyes, respiratory system and skin.
Ro-31-8425, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014


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