557514
Ro-31-8425
2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
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01 junio 2012
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A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε).
| Información sobre producto | |||
|---|---|---|---|
| Form | Reddish-orange solid | ||
| Primary Target | PKC | ||
| Primary Target IC50 | 15 nM | ||
| Secondary target | PKCα (IC50 = 8 nM), PKCβI (IC50 = 8 nM), PKCβII (IC50 = 14 nM) | ||
| Protect from Light | Si | ||
| Purity | ≥94% by HPLC | ||
| Fórmula químico | C26H24N4O2 · HCl | ||
| Número CAS | 131848-97-0 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 26-36 |
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| Frase R |
R: 36/37/38 |
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