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Merck KGaA
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64293 Darmstadt
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01 junio 2012
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A potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway (IC50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells) by binding directly to Smoothened (Smo; Kd = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay).
| Información sobre producto | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | antagonist of the Shh (Sonic Hedgehog) signaling pathway | ||
| Primary Target IC50 | 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells | ||
| Secondary target | activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay) | ||
| Protect from Light | Si | ||
| Packaged under inert gas | Si | ||
| Cell permeable | Si | ||
| Purity | ≥95% by HPLC | ||
| Fórmula químico | C23H27N5 | ||
| Número CAS | 304909-07-7 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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