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234415 C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem

The C5a Receptor Antagonist, W-54011, also referenced under CAS 405098-33-1, controls the biological activity of C5a Receptor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-((4-Dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide, HCl

Primary Target: C5a Receptor
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234415
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
405098-33-1C₃₀H₃₆N₂O₂ • HCl

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234415-1MG
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      234415-5MG
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          Description
          OverviewA tetrahydronaphthalenyl carboxamide compound that acts as a potent, specific and orally active C5a receptor antagonist. Shown to inhibit the binding of 125I-rhC5a to human neutrophils with a Ki of 2.2 nM, as well as C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation (IC50 = 3.1 nM, 2.7 nM and 1.6 nM, respectively) with no agonist activity up to 10 µM. Shown to prevent C5a-induced neutrophenia in gerbils (100 µg/kg i.v. or 3-30 mg/kg orally).
          Catalogue Number234415
          Brand Family Calbiochem®
          SynonymsN-((4-Dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide, HCl
          References
          ReferencesSumichika, H., et al. 2002. J. Biol. Chem. 277, 49403.
          Product Information
          CAS number405098-33-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₀H₃₆N₂O₂ • HCl
          Chemical formulaC₃₀H₃₆N₂O₂ • HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetC5a Receptor
          Primary Target IC<sub>50</sub>3.1 nM, 2.7 nM and 1.6 nM against C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation, respectively
          Primary Target K<sub>i</sub>2.2 nM against the binding of 125I-rhC5a to human neutrophils
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          234415-1MG 04055977200232
          234415-5MG 04055977200249

          Documentation

          C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          234415

          References

          Reference overview
          Sumichika, H., et al. 2002. J. Biol. Chem. 277, 49403.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-June-2008 RFH
          SynonymsN-((4-Dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide, HCl
          DescriptionA potent, specific, and orally active C5a receptor antagonist. Shown to inhibit the binding of 125I-rhC5a to human neutrophils with a Ki of 2.2 nM, as well as C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation (IC50 = 3.1 nM, 2.7 nM and 1.6 nM, respectively) with no agonist activity up to 10 µM. Shown to prevent C5a-induced neutrophenia in gerbils (100 µg/kg i.v. or 3-30 mg/kg orally).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number405098-33-1
          Chemical formulaC₃₀H₃₆N₂O₂ • HCl
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml) or Methanol (50 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSumichika, H., et al. 2002. J. Biol. Chem. 277, 49403.