513000  PD 98059

2′-Amino-3′-methoxyflavone, MEK Inhibitor V

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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Phone: +49 6151 72-0
Fax: +49 6151 72 2000


17 เมษายน 2557

Product number Qty/Pk Quantity Price
513000-10MG  10 mg  loading
513000-25MG  25 mg  loading
513000-5MG  5 mg  loading
Selective, reversible, and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase in MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 µM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the p140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Blocks LPS-induced activation of TNF-α gene expression. Inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. A 5 mg/ml solution of PD 98059 (Cat. No. 513001) in anhydrous DMSO is also available.
Product information
Form Pale yellow solid
Molar mass 267.3
Protect from Light Yes
Purity ≥98% by HPLC
Solubility DMSO or MeOH
Chemical formula C16H13NO3
CAS number 167869-21-8
Store and ship information
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
PD 98059, molecular structure

© Merck KGaA, Darmstadt, Germany, 2557


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