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Strat-M® Membrane Correlation Data

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Are you testing active compounds for transdermal diffusion?
Optimizing your formulations? Using enhancers?
Performing safety testing on your formulations?

Strat-M® membrane is predictive of diffusion in human skin for a wide range of compounds and formulations. Use the Compound Correlation Tool to learn how well Strat-M® membrane will work for you.


Strat-M® membrane has broad chemical compatibility and is an appropriate test model for compounds across a wide range of physiochemical properties. Seven test compounds ranging in molecular weight from 180 to 392 with log P values (representing relative lipophilicity) of -0.131 to 6.9 were tested for diffusion through human skin and Strat-M® membrane. The flux of each compound through human skin and through Strat-M® membrane was nearly equivalent, with a mean flux ratio of 1.14.

Strat-M® membrane correlation factor compared to human skin
Data points were calculated from the ratios of average values for cumulative flux of seven compounds through Strat-M® and human cadaver skin, measured at 8 hours. The solid line represents the ideal 1:1 correlation. More details on the test conditions can be found on the flux charts of the individual compounds.

Diffusion Rate

Whether you are safety testing a slowly diffusing sunscreen active, or optimizing a rapidly diffusing NSAID formulation for pain relief, Strat-M® membrane provides the versatility to generate meaningful data.

Strat-M® membrane diffusion rate compared to human skin
Transdermal diffusion testing was conducted for several formulations with varying diffusion rates to assess correlation between Strat-M® membrane and human cadaver skin. Six Franz cells were used for each formulation—three with Strat-M® membrane and three with human cadaver skin. The donor chambers were loaded with 500 µL of the formulations. Samples were collected hourly and analyzed by HPLC. The results showed correlation between human skin and Strat-M® membrane over a range of diffusion rates.

Sensitive to Enhancers

Strat-M® membrane exhibits differential permeability in the presence of enhancers, so it is appropriate for use during formulation optimization.

Strat-M® membrane cumulative flux compared to human skin
Caffeine Solution in Propylene Glycol & Propylene Glycol + Oleic Acid showing similar diffusion behavior between human skin and Strat-M® membrane as a permeation enhancer (Oleic acid) is added to the formulation.

Note: Information presented is based on preliminary development tests. Official claims will be based on product validation results.