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531978 ATM Inhibitor, KU 60019 - CAS 925701-46-8 - Calbiochem

ATM kinase inhibitor, KU60019, is a cell permeable, potent inhibitor of ATM kinase inhibitor (IC₅₀ = 6.3 nM). Has 270 & 1600-fold higher selectivity over DNA-PK and ATR kinase.

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Synonyme: KU-60019, KU60019, Ataxia Telangiectasia Mutate Kinase Inhibitor

Primary Target: ATM
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531978
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
925701-46-8C₃₀H₃₃N₃O₅S

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      Description
      OverviewA cell permeable thioxanthene based compound that acts as a highly potent inhibitor of Ataxia telangiectasia mutate (ATM) kinase inhibitor (IC50 = 6.3 nM). Displays about 270 and 1600-fold greater selectivity over DNA-PK and ATR kinase (IC50 = 1.7 and >10 µM, respectively). Has only a trivial effect on 229 protein kinases when screened in a panel at 1 µM level. Shown to block Ser15 phosphorylation of p53 and basal and radiation-induced Ser473 phosphorylation of Akt in glioma cells. Blocks radiation-induced DNA damage response and radiosensitizes human glioma cells (U87 and U1242) and mouse glioma stem cells and inhibits glioma cell migration, invasion, and growth. Also radiosensitizes orthotopic glioma xenografts and significantly extends the survival of mice.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number531978
      Brand Family Calbiochem®
      SynonymsKU-60019, KU60019, Ataxia Telangiectasia Mutate Kinase Inhibitor
      References
      ReferencesBiddlestone-Thorpe, L., et al. 2013. Clin. Cancer Res. 19, 3189.
      Golding, S., et al. 2009. Mol. Cancer Ther. 8, 2894.
      Product Information
      CAS number925701-46-8
      FormLight beige solid
      Hill FormulaC₃₀H₃₃N₃O₅S
      Chemical formulaC₃₀H₃₃N₃O₅S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetATM
      Primary Target IC<sub>50</sub>6.3 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5319780001 04055977287127

      Documentation

      ATM Inhibitor, KU 60019 - CAS 925701-46-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Biddlestone-Thorpe, L., et al. 2013. Clin. Cancer Res. 19, 3189.
      Golding, S., et al. 2009. Mol. Cancer Ther. 8, 2894.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-November-2015 JSW
      SynonymsKU-60019, KU60019, Ataxia Telangiectasia Mutate Kinase Inhibitor
      DescriptionA cell permeable thioxanthene based compound that acts as a highly potent inhibitor of Ataxia telangiectasia mutate (ATM) kinase inhibitor (IC50 = 6.3 nM). Displays about 270 and 1600-fold greater selectivity over DNA-PK and ATR kinase (IC50 = 1.7 and >10 µM, respectively). Has only a trivial effect on 229 protein kinases when screened in a panel at 1 µM level. Shown to block Ser15 phosphorylation of p53 and basal and radiation-induced Ser473 phosphorylation of Akt in glioma cells. Blocks radiation-induced DNA damage response and radiosensitizes human glioma cells (U87 and U1242) and mouse glioma stem cells and inhibits glioma cell migration, invasion, and growth. Also radiosensitizes orthotopic glioma xenografts and significantly extends the survival of mice.
      FormLight beige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number925701-46-8
      Chemical formulaC₃₀H₃₃N₃O₅S
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBiddlestone-Thorpe, L., et al. 2013. Clin. Cancer Res. 19, 3189.
      Golding, S., et al. 2009. Mol. Cancer Ther. 8, 2894.