175580 Sigma-AldrichAngiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem
The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: (Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
Empfohlene Produkte
Übersicht
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 186611-44-9 | C₁₂H₉N₃O |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 175580-10MG |
|
Kst.-Ampulle | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM). |
| Catalogue Number | 175580 |
| Brand Family | Calbiochem® |
| Synonyms | (Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one |
| References | |
|---|---|
| References | Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243. |
| Product Information | |
|---|---|
| CAS number | 186611-44-9 |
| ATP Competitive | Y |
| Form | Yellow solid |
| Hill Formula | C₁₂H₉N₃O |
| Chemical formula | C₁₂H₉N₃O |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | hEGF-R tyrosine kinase activity |
| Primary Target IC<sub>50</sub> | 54% inhibition at 10 µM against hEGF-R tyrosine kinase activity |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Bestellnummer | GTIN |
| 175580-10MG | 04055977222920 |
Documentation
Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem SDB
| Titel |
|---|
Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 175580 |
Literatur
| Übersicht |
|---|
| Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243. |