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MABC195 Anti-FYVE Antibody, clone 7F11.1

Anti-FYVE Antibody, clone 7F11.1 detects level of FYVE & has been published & validated for use in FYVE.

Anti-FYVE Antibody, clone 7F11.1: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: ZFYVE26 UniProt Number: Q68DK2
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MABC195
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC195
      DescriptionAnti-FYVE Antibody, clone 7F11.1
      Alternate Names
      • Zinc finger FYVE domain-containing protein 26
      • FYVE domain-containing centrosomal protein
      • FYVE-CENT
      • Spastizin
      • FYVE
      Background InformationFYVE, also known as Zinc finger FYVE domain-containing protein 26, or FYVE domain-containing centrosomal protein (FYVE-CENT), or Spastizin, and encoded by the gene ZFYVE26/KIAA0321, is a phosphosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis. FYVE is recruited to the midbody during cytokinesis and acts as a regulator of abscission. FYVE also be required for efficient homologous recombination DNA double-strand break repair. FYVE is cytoskeleton associated and localized in the cytoplasm in resting cells but at the centrosome during cell division. FYVE is expressed in all cells and tissues. Defects in FYVE may be associated with Spastic paraplegia 15, a form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-FYVE Antibody, clone 7F11.1 detects level of FYVE & has been published & validated for use in FYVE.
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemisty Analysis: A 1:50 dilution from a representative lot detected FYVE in human frontal cortex and thalamus tissues.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human FYVE.
      Clone7F11.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ZFYVE26
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~285 kDa calculated. Four isoforms are known to exist at 285 kDa (isoform 1), 283 kDa (isoform 2), 78 kDa (isoform 3), and 89 kDa (isoform 4).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human cerebellum tissue.

      Immunohistochemisty Analysis: A 1:50 dilution from a representative lot detected FYVE in human cerebellum tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABC195 04053252943201