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219379 Cathepsin K Inhibitor II - Calbiochem

The Cathepsin K Inhibitor II controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Cathepsin K Inhibitor II - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Inhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc

Primary Target: cathepsin K
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₃₅H₅₁N₇O₈
      Description
      OverviewA cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1 µM. At higher concentrations, also inhibits the activities of cathepsin B and papain (Ki,app = 510 nM, 1.2 µM, respectively). Does not significantly inhibit cathepsin L.
      Catalogue Number219379
      Brand Family Calbiochem®
      SynonymsInhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc
      References
      ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.
      Product Information
      ATP CompetitiveN
      FormLyophilized white solid
      Hill FormulaC₃₅H₅₁N₇O₈
      Chemical formulaC₃₅H₅₁N₇O₈
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin K
      Primary Target K<sub>i</sub>6 nM against cathepsin; 510 nM, 1.2 µM, against cathepsin B and papain, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceBoc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      219379 0

      Documentation

      Cathepsin K Inhibitor II - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Cathepsin K Inhibitor II - Calbiochem Analysenzertifikate

      TitelChargennummer
      219379

      Literatur

      Übersicht
      Wang, D., et al. 2002. Biochemistry 41, 8849.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-June-2008 RFH
      SynonymsInhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc
      DescriptionA cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki = 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (Ki = 510 nM and 1.2 µM, respectively). Does not significantly inhibit cathepsin L.
      FormLyophilized white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₅H₅₁N₇O₈
      Peptide SequenceBoc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.