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400088 HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem

The HIF-1α Translation Inhibitor, KC7F2, also referenced under CAS 927822-86-4, controls the biological activity of HIF-1α. This small molecule/inhibitor is primarily used for Cell Structure applications.

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Synonyme: Hypoxia-Inducible Factor-1α Translation Inhibitor, KC7F2, N,Nʹ-(2,5-Dichlorosulfonyl)cystamine, HIF Inhibitor III

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      927822-86-4C₁₆H₁₆Cl₄N₂O₄S₄
      Description
      OverviewA cell-permeable symmetrical cystamine compound that selectively suppresses cellular HIF-1α, but not HIF-1β, protein synthesis without affecting the transcription of HIF-1α mRNA or the stability of HIF-1α protein. Reduction of cellular HIF-1α by KC7F2 treatment (IC50 <20 µM in LN229 cultures under hypoxia condition) is shown to result in decreased transcriptions of HIF-1α-dependent genes, such as CA IX, endothelin 1, enolase 1, and MMP-2. Inhibition of 4EBP1 and S6K phosphorylation, important event for the initiation of protein translation, is also observed in KC7F2 and U87MGD cultures following KC7F2 treatment under hypoxia condition, which may account for, at least in part, the downregulated HIF-1α synthesis.
      Catalogue Number400088
      Brand Family Calbiochem®
      SynonymsHypoxia-Inducible Factor-1α Translation Inhibitor, KC7F2, N,Nʹ-(2,5-Dichlorosulfonyl)cystamine, HIF Inhibitor III
      References
      ReferencesNarita, T., et al. 2009. Clin. Cancer Res. 15, 6128.
      Product Information
      CAS number927822-86-4
      FormBeige to tan solid
      Hill FormulaC₁₆H₁₆Cl₄N₂O₄S₄
      Chemical formulaC₁₆H₁₆Cl₄N₂O₄S₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      400088 0

      Documentation

      HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      400088

      Literatur

      Übersicht
      Narita, T., et al. 2009. Clin. Cancer Res. 15, 6128.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsHypoxia-Inducible Factor-1α Translation Inhibitor, KC7F2, N,Nʹ-(2,5-Dichlorosulfonyl)cystamine, HIF Inhibitor III
      DescriptionA cell-permeable symmetrical cystamine compound that selectively suppresses cellular HIF-1α, but not HIF-1β, protein synthesis without affecting the transcription of HIF-1α mRNA or the stability of HIF-1α protein. Reduction of cellular HIF-1α by KC7F2 treatment (IC50 <20 µM in LN229 cultures under hypoxia condition) is shown to result in decreased transcriptions of HIF-1α-dependent genes, such as CA IX, endothelin 1, enolase 1, and MMP-2. Inhibition of 4EBP1 and S6K phosphorylation, important event for the initiation of protein translation, is also observed in KC7F2 and U87MGD cultures following KC7F2 treatment under hypoxia condition, which may account for, at least in part, the downregulated HIF-1α synthesis.
      FormBeige to tan solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number927822-86-4
      Chemical formulaC₁₆H₁₆Cl₄N₂O₄S₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNarita, T., et al. 2009. Clin. Cancer Res. 15, 6128.