401479 Sigma-AldrichIKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem
The IKK-2 Inhibitor, SC-514, also referenced under CAS 354812-17-2, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
More>> The IKK-2 Inhibitor, SC-514, also referenced under CAS 354812-17-2, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: SC-514
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 354812-17-2 | C₉H₈N₂OS₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 401479-1MG |
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Kst.-Ampulle | 1 mg |
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| Description | |
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| Overview | A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 = ~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF. A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401485) in DMSO is also available. |
| Catalogue Number | 401479 |
| Brand Family | Calbiochem® |
| Synonyms | SC-514 |
| References | |
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| References | Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817. Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861. |
| Product Information | |
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| CAS number | 354812-17-2 |
| ATP Competitive | Y |
| Form | Pale yellow solid |
| Hill Formula | C₉H₈N₂OS₂ |
| Chemical formula | C₉H₈N₂OS₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | IKK-2 |
| Primary Target IC<sub>50</sub> | 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 401479-1MG | 07790788055806 |
Documentation
IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem SDB
| Titel |
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IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 401479 |
Literatur
| Übersicht |
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| Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817. Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861. |