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438187 InSolution™ Lovastatin, Sodium Salt - Calbiochem

Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Primary Target: HMG-CoA reductase
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₄H₃₇O₆ • Na
      Description
      OverviewCarboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as a reversible competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
      Catalogue Number438187
      Brand Family Calbiochem®
      References
      ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
      Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
      McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
      Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
      Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
      Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
      Product Information
      FormLiquid
      FormulationA 10 mM (5 mg/1.13 ml) solution of Lovastatin, Sodium Salt (Cat. No. 438186) in H₂O.
      Hill FormulaC₂₄H₃₇O₆ • Na
      Chemical formulaC₂₄H₃₇O₆ • Na
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHMG-CoA reductase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 24/25

      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Harmful
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      438187 0

      Documentation

      InSolution™ Lovastatin, Sodium Salt - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      InSolution™ Lovastatin, Sodium Salt - Calbiochem Analysenzertifikate

      TitelChargennummer
      438187

      Literatur

      Übersicht
      Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
      Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
      McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
      Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
      Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
      Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2013 JSW
      DescriptionCarboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as a reversible competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
      FormLiquid
      FormulationA 10 mM (5 mg/1.13 ml) solution of Lovastatin, Sodium Salt (Cat. No. 438186) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₃₇O₆ • Na
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Toxicity Harmful
      ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
      Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
      McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
      Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
      Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
      Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.