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438186 Lovastatin, Sodium Salt - Calbiochem

Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.

Lovastatin, Sodium Salt - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: L-Type Calcium Channel Blocker IV

Primary Target: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₄H₃₇O₆ • Na
      Description
      OverviewCarboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays.
      Catalogue Number438186
      Brand Family Calbiochem®
      SynonymsL-Type Calcium Channel Blocker IV
      References
      ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
      Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
      McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
      Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
      Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
      Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
      Product Information
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₄H₃₇O₆ • Na
      Chemical formulaC₂₄H₃₇O₆ • Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary Target3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      438186 0

      Documentation

      Lovastatin, Sodium Salt - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Lovastatin, Sodium Salt - Calbiochem Analysenzertifikate

      TitelChargennummer
      438186

      Literatur

      Übersicht
      Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
      Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
      McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
      Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
      Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
      Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      SynonymsL-Type Calcium Channel Blocker IV
      DescriptionCarboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₃₇O₆ • Na
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (50 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
      Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
      McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
      Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
      Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
      Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.