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526559 PI3Kδ Inhibitor, SW30 - Calbiochem

The PI3Kδ Inhibitor, SW30 controls the biological activity of PI3Kδ. This small molecule/inhibitor is primarily used for Membrane applications.

PI3Kδ Inhibitor, SW30 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, PI 3-K Inhibitor XIV

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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₅H₂₁N₇O₂
      Description
      OverviewA cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kδ (IC50 = 7 nM, 1300 nM, 85000 nM, and 740 nM for PI 3-Kδ PI 3-Kγ PI 3-Kα and PI 3-Kβ, respectively) in an enzymatic assay with an EC50 = 16 nM for PI 3-Kδ and 2.7 µM for PI 3-Kγ in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370 nM and 10 µM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells.
      Catalogue Number526559
      Brand Family Calbiochem®
      Synonyms2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, PI 3-K Inhibitor XIV
      References
      ReferencesWilliams, O., et al. 2010. Chem Biol. 17, 123.
      Product Information
      FormWhite solid
      Hill FormulaC₂₅H₂₁N₇O₂
      Chemical formulaC₂₅H₂₁N₇O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      526559 0

      Documentation

      PI3Kδ Inhibitor, SW30 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      PI3Kδ Inhibitor, SW30 - Calbiochem Analysenzertifikate

      TitelChargennummer
      526559

      Literatur

      Übersicht
      Williams, O., et al. 2010. Chem Biol. 17, 123.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-June-2011 RFH
      Synonyms2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, PI 3-K Inhibitor XIV
      DescriptionA cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kδ (IC50 = 7 nM, 1300 nM, 85000 nM, and 740 nM for PI 3-Kδ, PI 3-Kγ PI 3-Kα and PI 3-Kβ, respectively) in an enzymatic assay with an EC50 = 16 nM for PI 3-Kδ and 2.7 µM for PI 3-Kγ in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370 nM and 10 µM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells.
      FormWhite solid
      Chemical formulaC₂₅H₂₁N₇O₂
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesWilliams, O., et al. 2010. Chem Biol. 17, 123.