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574102 Sulindac Sulfide - CAS 32004-67-4 - Calbiochem

A cell-permeable, active metabolite of Sulindac.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid

Primary Target: COX-1
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      32004-67-4C₂₀H₁₇FO₂S
      Description
      OverviewA cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Preferentially inhibits the secretion of Aβ42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L.
      Catalogue Number574102
      Brand Family Calbiochem®
      Synonyms(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
      References
      ReferencesWeggen, S., et al. 2001. Nature 414, 212.
      Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.
      Herrmann, C., et al. 1998. Oncogene 17, 1769.
      Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.
      Arber, N., et al. 1997. Gastroenterology 113, 1892.
      Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
      Product Information
      CAS number32004-67-4
      ATP CompetitiveN
      FormYellow-orange solid
      Hill FormulaC₂₀H₁₇FO₂S
      Chemical formulaC₂₀H₁₇FO₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-1
      Primary Target IC<sub>50</sub>ID50 = 500 nM against COX-1
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-42/43-63

      Harmful if swallowed.
      May cause sensitization by inhalation and skin contact.
      Possible risk of harm to the unborn child.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      574102 0

      Documentation

      Sulindac Sulfide - CAS 32004-67-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Sulindac Sulfide - CAS 32004-67-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      574102

      Literatur

      Übersicht
      Weggen, S., et al. 2001. Nature 414, 212.
      Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.
      Herrmann, C., et al. 1998. Oncogene 17, 1769.
      Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.
      Arber, N., et al. 1997. Gastroenterology 113, 1892.
      Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      Synonyms(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
      DescriptionAn active metabolite of the non-steroidal anti-inflammatory drug Sulindac (Cat. No. 574100). Inhibits Ras signaling. Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits cell growth and induces apoptosis in a time-and dose-dependent manner. Selectively inhibits prostaglandin H synthase-1 (PGHS-1; COX-1; ID50 = 0.5 µM) relative to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Reduces Aβ42 production independently of COX inhibition.
      FormYellow-orange solid
      CAS number32004-67-4
      Chemical formulaC₂₀H₁₇FO₂S
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (25 mg/ml) or ethanol (5 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesWeggen, S., et al. 2001. Nature 414, 212.
      Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.
      Herrmann, C., et al. 1998. Oncogene 17, 1769.
      Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.
      Arber, N., et al. 1997. Gastroenterology 113, 1892.
      Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.