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  • Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. 19490090

    In the mammalian brain, neural stem and progenitor cells in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus generate new neurons throughout adulthood. The generation of new functional neurons is a complex process that is tightly controlled by extrinsic signals and that is characterized by stage-specific gene expression programs and cell biological processes. The transcription factors regulating such stage-specific developmental steps in adult neurogenesis are largely unknown. Here we report that Sox11, a member of the group C Sox transcription factor family, is prominently expressed in the neurogenic areas of the adult brain. Further analysis revealed that Sox11 expression is strictly confined to doublecortin-expressing neuronally committed precursors and immature neurons but that Sox11 is not expressed in non-committed Sox2-expressing precursor cells and mature neurons of the adult neurogenic lineage. Finally, overexpression of Sox11 promotes the generation of doublecortin-positive immature neurons from adult neural stem cells in vitro. These data indicate that Sox11 is involved in the transcriptional regulation of specific gene expression programs in adult neurogenesis at the stage of the immature neuron.
    Dokumententyp:
    Referenz
    Produkbestellnummer:
    AB5776
    Produktbezeichnung:
    Anti-Sox11 Antibody, pain

  • Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis. 30385877

    The intellectual disability gene, Sox11, encodes for a critical neurodevelopmental transcription factor with functions in precursor survival, neuronal fate determination, migration and morphogenesis. The mechanisms regulating SOX11's activity remain largely unknown. Mass spectrometric analysis uncovered that SOX11 can be post-translationally modified by phosphorylation. Here, we report that phosphorylatable serines surrounding the high-mobility group box modulate SOX11's transcriptional activity. Through Mass Spectrometry (MS), co-immunoprecipitation assays and in vitro phosphorylation assays followed by MS we verified that protein kinase A (PKA) interacts with SOX11 and phosphorylates it on S133. In vivo replacement of SoxC factors in developing adult-generated hippocampal neurons with SOX11 S133 phospho-mutants indicated that phosphorylation on S133 modulates dendrite development of adult-born dentate granule neurons, while reporter assays suggested that S133 phosphorylation fine-tunes the activation of select target genes. These data provide novel insight into the control of the critical neurodevelopmental regulator SOX11 and imply SOX11 as a mediator of PKA-regulated neuronal development.
    Dokumententyp:
    Referenz
    Produkbestellnummer:
    Mehrere
    Produktbezeichnung:
    Mehrere

  • Anti-Sox11 - 2499184

    Dokumententyp:
    Analysenzertifikat
    Chargennummer:
    2499184
    Produkbestellnummer:
    ABN105
    Produktbezeichnung:
    Anti-Sox11 Antibody

  • Anti-Sox11 -2615096

    Dokumententyp:
    Analysenzertifikat
    Chargennummer:
    2615096
    Produkbestellnummer:
    ABN105
    Produktbezeichnung:
    Anti-Sox11 Antibody

  • Anti-Sox11 - Q2048853

    Dokumententyp:
    Analysenzertifikat
    Chargennummer:
    Q2048853
    Produkbestellnummer:
    ABN105
    Produktbezeichnung:
    Anti-Sox11 Antibody