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Merck

202398

Poly(éthylène glycol)

greener alternative

average Mn 400, hydroxyl

Synonyme(s) :

PEG

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A propos de cet article

Formule linéaire :
H(OCH2CH2)nOH
Numéro CAS:
25322-68-3
UNSPSC Code:
12352104
PubChem Substance ID:
24852060
NACRES:
NA.23
MDL number:
MFCD00081839

Principaux documents

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Nom du produit

Poly(éthylène glycol), average Mn 400

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

form

viscous liquid

mol wt

Mn 380-420, average Mn 400

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

refractive index

n20/D 1.466

pH

4.5-7.5

viscosity

7.3 cSt(210 °F)(lit.)

mp

4-8 °C (lit.)

density

1.128 g/mL

Ω-end

hydroxyl

α-end

hydroxyl

greener alternative category

Aligned,

Quality Level

200

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Catégories apparentées

General description

Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. PEGs are non-toxic, FDA-approved, generally non-immunogenic, and frequently used in many biomedical applications including bioconjugation, drug delivery, surface functionalization, and tissue engineering. In drug delivery, PEGs can be used as linkers for antibody-drug conjugates (ADCs) or as a surface coating on nanoparticles to improve systemic drug delivery.

Application

Poly(ethylene glycol) (PEG) has been used as a coating agent for the synthesis and in vitro safety assessment of magnetic bacterial cellulose (MBC) pellicles, performed on porcine aortic smooth muscle cells (PAOSMC). PEG provides a compatible surface for cell culture, since uncoated iron oxide NPs are considered cytotoxic to cells. It has also been used as a plasticizer in investigating the effectiveness of polyvinylpyrrolidone microneedles for transdermal delivery of functional collagen using porcine skin, adult human skin analog and human foreskin. Microneedles obtained, were reportedly characterized by various analytical and bio-analytical techniques.
Solvent for greener fluorination of acetoacetamides with Selectfluor®.

Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400
Used in conjunction with carbon black to form a conductive composite. Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.

Legal Information

Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany

Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCP0910
MKCZ7545
BCCN6279
MKCZ1709
MKCX8951

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Transdermal delivery of functional collagen via polyvinylpyrrolidone microneedles
Sun W, et al.
Annals of Biomedical Engineering, 43(12), 2978-2990 (2015)
Changxin Wan et al.
Cancer research, 81(1), 158-173 (2020-11-08)
Immune therapies have had limited efficacy in high-grade serous ovarian cancer (HGSC), as the cellular targets and mechanism(s) of action of these agents in HGSC are unknown. Here we performed immune functional and single-cell RNA sequencing transcriptional profiling on novel
Synthesis and in vitro safety assessment of magnetic bacterial cellulose with porcine aortic smooth muscle cells
Pastrana FH, et al.
Journal of Biomedical Materials Research Part A, 104(11), 2801-2809 (2016)
Akashi, M., Akagi, T.
Yuki Gosei Kaguku Kyokaishi, 65, 520-520 (2004)
Ruth Hernandez-Perez et al.
Physical review. E, 96(6-1), 062803-062803 (2018-01-20)
The evaporation of droplets can give rise to a wide range of interesting phenomena in which the dynamics of the evaporation are crucial. In this work, we find simple scaling laws for the evaporation dynamics of axisymmetric droplets pinned on
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