202509
Poly(ethylene glycol) methyl ether
average Mn 2,000, methoxy, hydroxyl
Synonyme(s) :
Polyethylene glycol, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG
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A propos de cet article
Formule linéaire :
CH3(OCH2CH2)nOH
Numéro CAS:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
MDL number:
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Poly(ethylene glycol) methyl ether, average Mn ~2,000
vapor density
>1 (vs air)
vapor pressure
0.05 mmHg ( 20 °C)
form
flakes (or pellets)
mol wt
average Mn ~2,000
viscosity
54.6 cSt(210 °F)(lit.)
transition temp
Tm 52 °C
functional group
hydroxyl
SMILES string
O(CCO)C
InChI
1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
InChI key
XNWFRZJHXBZDAG-UHFFFAOYSA-N
General description
It is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether. Etherification of the PEG chain ends can be undertaken in basic conditions by reacting it with alkyl halides. mPEG can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.
Application
Poly(ethylene glycol) methyl ether-attached dendrimers can be used as carriers for anticancer drugs. This novel drug carrier has a biocompatible surface and an interior for the encapsulation of drugs.
It can be used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.
It can also be used as a starting material in the preparation of a biodegradable amphiphilic copolymer of poly(L-alanine) with mPEG.
It can be used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.
It can also be used as a starting material in the preparation of a biodegradable amphiphilic copolymer of poly(L-alanine) with mPEG.
Features and Benefits
Inserting poly(ethylene glycol) methyl ether (mPEG) side chain enhances the hydrophilicity and flexibility of the polymer matrix.
Classe de stockage
11 - Combustible Solids
wgk
WGK 1
flash_point_f
359.6 °F - closed cup
flash_point_c
182 °C - closed cup
ppe
Eyeshields, Gloves
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Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in
Pengxiang Zhao et al.
Chemical communications (Cambridge, England), 49(31), 3218-3220 (2013-03-14)
"Click" chemistry now offers access to a great variety of triazoles, and the first example of a strategy to stabilize gold nanoparticles (AuNPs) with a new 1,2,3-triazole-mPEG ligand is developed here together with preliminary examples of possible applications.
Lina Du et al.
Anti-cancer drugs, 24(2), 172-180 (2012-09-20)
A functionalized poly(amidoamine) (PAMAM) nanocarrier was designed and prepared to deliver anticancer drugs. The nanocarrier is a copolymer with a core-shell structure with 3.0 G PAMAM as the core and sequentially conjugated poly(2-(N,N-diethylamino)ethyl methacrylate) (pDEA) and methoxy-poly(ethylene glycol) 2000 (mPEG)