317519
Methyl 2-acetamidoacrylate
98%
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A propos de cet article
Formule linéaire :
H2C=C(NHCOCH3)CO2CH3
Numéro CAS:
Poids moléculaire :
143.14
NACRES:
NA.23
PubChem Substance ID:
UNSPSC Code:
12162002
MDL number:
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1S/C6H9NO3/c1-4(6(9)10-3)7-5(2)8/h1H2,2-3H3,(H,7,8)
SMILES string
COC(=O)C(=C)NC(C)=O
InChI key
SMWNFFKPVLVOQQ-UHFFFAOYSA-N
assay
98%
bp
104 °C/8 mmHg (lit.)
mp
50-52 °C (lit.)
Quality Level
Catégories apparentées
General description
Conjugated addition of secondary amines, imidazole and pyrazole to methyl 2 methyl 2-acetamidoacrylate in the presence of a catalyst results in the formation of β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives. Methyl-2-acetamidoacrylate (M2AA) is an anti-inflammatory agent. The catalytic reaction of methyl 2-acetamidoacrylate with Grignard′s reagents affords α-amino esters. M2AA can form thermosensitive copolymers with methyl acrylate.
Methyl ester of 2-acetamidoacrylate . methyl 2-acetamidoacrylate (Me-2-AA) is a di-unsaturated α-amino acid derivative. methyl-2-acetamidoacrylate exihibits anti -inflammatory properties, it is very effective against lipopolysaccharide (LPS)- induced nitric oxide production by RAW 264.
Application
Methyl 2-acetamidoacrylate can undergo [2+2] cycloaddition (Michael–Dieckmann-type reaction) with ketene diethyl acetal to yield the cyclobutane core. It may be used in rhodium-catalyzed 2-alkenylpyrrole formation.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Rh diphosphine complexes using DuPhos and JosiPhos as chiral ligands have been immobilised by ion exchange into the mesoporous material MCM-41. When used as catalysts for the enantioselective hydrogenation of dimethyl itaconate and methyl-2-acetamidoacrylate, these heterogeneous catalysts give catalytic performance
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Besset T, et al.
European Journal of Chemistry, 17(26), 7167-7171 (2011)
Ethyl pyruvate: a novel anti?inflammatory agent.
Fink MP, et al.
J. Int. Med., 261(4), 349-362 (2007)
Benoît Cossec et al.
Molecules (Basel, Switzerland), 13(10), 2394-2407 (2008-10-03)
A safe and simple method for methyl S-arylmercapturate synthesis is described. Thirteen such compounds, to be used afterwards in metabolism studies, have been obtained with yields ranging from 71 to 99.6%. These compounds were obtained using a sulfa-Michael addition and
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