361860
Deuterium
99.8 atom % D
Synonyme(s) :
D2
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A propos de cet article
Formule linéaire :
D2
Numéro CAS:
Poids moléculaire :
4.03
NACRES:
NA.12
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
Isotopic purity:
99.8 atom % D
Assay:
99.995% (CP)
Mass shift:
M+2
Form:
gas (compressed)
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Laissez-nous vous aiderInChI key
UFHFLCQGNIYNRP-VVKOMZTBSA-N
SMILES string
[2H][2H]
InChI
1S/H2/h1H/i1+1D
vapor density
0.07 (vs air)
isotopic purity
99.8 atom % D
assay
99.995% (CP)
form
gas (compressed)
bp
-249.5 °C (lit.)
density
0.169 g/mL at -250.9 °C (liq)(lit.), 0.165 g/L at 25 °C (gas)
Quality Level
application(s)
electronics
mass shift
M+2
storage temp.
room temp
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Catégories apparentées
General description
Deuterium 99.8 atom % D is a high-purity isotope product with a unique chemical profile that belongs to the class of isotopes. Produced by Sigma-Aldrich, we are committed to providing quality isotope products and a reliable supply chain. Available in industrial and pre-pack quantities.
Application
- Deuterium labeling for metabolic and pharmacokinetic studies
- synthesis of deuterated reference standards
- Isotope effect investigations in reaction mechanisms
- Chemical synthesis of labeled compounds
- synthesis of deuterated reference standards
- Isotope effect investigations in reaction mechanisms
- Chemical synthesis of labeled compounds
Features and Benefits
Features
- High deuterium content for effective labeling
- Versatile application in drug development
- Enhances metabolic stability of compounds
- Supports innovative pharmaceutical research
Benefits
- Accelerates drug discoverytimelines
- Improves the accuracy of pharmacokinetic studies
- Increases the robustness of formulations
- Supports the development of next-generation therapies
- High deuterium content for effective labeling
- Versatile application in drug development
- Enhances metabolic stability of compounds
- Supports innovative pharmaceutical research
Benefits
- Accelerates drug discoverytimelines
- Improves the accuracy of pharmacokinetic studies
- Increases the robustness of formulations
- Supports the development of next-generation therapies
Packaging
All gas volumes are quoted at Normal Temperature and Pressure (NTP) and not at Standard Temperature and Pressure (STP).
Standard products are packaged in a 450 mL carbon steel lecture bottle with brass CGA 110/180 valve. Nominal gas pressures at 21ºC are 330 psig for 10 L, 850 psig for 25 L, and 1570 psig for 45 L. Care must be taken when extracting this product from the cylinder.
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
Other Notes
Stainless steel control valves Z146951, Z187224 or either of stainless steel regulators Z148504 and Z148512 is recommended.
PTFE sealing washers GCA inlet size 180 Z146994
PTFE sealing washers CGA inlet size 110 Z146986
PTFE sealing washers GCA inlet size 180 Z146994
PTFE sealing washers CGA inlet size 110 Z146986
signalword
Danger
hcodes
Hazard Classifications
Flam. Gas 1A - Press. Gas Compr. Gas
Classe de stockage
2A - Gases
wgk
nwg
flash_point_f
<-238.0 °F - closed cup
flash_point_c
< -150 °C - closed cup
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Masaru Hoshino et al.
Biochimica et biophysica acta, 1768(8), 1886-1899 (2007-05-15)
A general method to analyze the structure of a supramolecular complex of amyloid fibrils at amino acid residue resolution has been developed. This method combines the NMR-detected hydrogen/deuterium (H/D) exchange technique to detect hydrogen-bonded amide groups and the ability of
Ying Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(36), 14604-14609 (2013-08-21)
Probing the conformational changes of amyloid beta (Aβ) peptide aggregation is challenging owing to the vast heterogeneity of the resulting soluble aggregates. To investigate the formation of these aggregates in solution, we designed an MS-based biophysical approach and applied it
Martin Byrdin et al.
Biochimica et biophysica acta, 1655(1-3), 64-70 (2004-04-22)
We review our work on electron transfer and proton dynamics during photoactivation in DNA photolyase from E. coli and discuss a recent theoretical study on this issue. In addition, we present unpublished data on the charge recombination between the fully
Xuguang Yan et al.
Molecular & cellular proteomics : MCP, 3(1), 10-23 (2003-11-19)
Electrospray ionization (ESI) mass spectrometry (MS) is a powerful analytical tool for elucidating structural details of proteins in solution especially when coupled with amide hydrogen/deuterium (H/D) exchange analysis. ESI charge-state distributions and the envelopes of charges they form from proteins
Michael Landreh et al.
The FEBS journal, 278(20), 3815-3821 (2011-06-15)
The study of protein structure and function has evolved to become a leading discipline in the biophysical sciences. Although it is not yet possible to determine 3D protein structures from MS data alone, multiple MS-based techniques can be combined to
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