49960
1-Oleoyl-rac-glycerol
technical, ~40% (TLC)
Synonyme(s) :
1-(cis-9-Octadecenoyl)-rac-glycerol, rac-Glycerol 1-monooleate, DL-α-Monoolein, Glyceryl cis-9-octadecenoate, Monoolein
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A propos de cet article
Formule linéaire :
CH3(CH2)7CH=CH(CH2)7COOCH2CHOHCH2OH
Numéro CAS:
Poids moléculaire :
356.54
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
203-827-7
Beilstein/REAXYS Number:
1728976
MDL number:
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Laissez-nous vous aiderInChI key
RZRNAYUHWVFMIP-KTKRTIGZSA-N
InChI
1S/C21H40O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h9-10,20,22-23H,2-8,11-19H2,1H3/b10-9-
SMILES string
O=C(CCCCCCC/C=C\CCCCCCCC)OCC(O)CO
description
non-ionic
grade
technical
concentration
~40% (TLC)
impurities
15-40% diglyceride, 15-40% triglyceride
functional group
ester, hydroxyl
Quality Level
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General description
1-Oleoyl-rac-glycerol is commonly known as monoolein (MO). It is an amphiphilic molecule that is made up of a glycerol backbone and a hydrocarbon chain.
Application
- Bovine Serum Albumin (BSA) Encapsulated in DODAB: MO (1: 2) Liposomes for Targeted Drug Delivery: Development and Characterization: This study focuses on developing liposomes consisting of Dioctadecyldimethylammonium Bromide (DODAB) and 1-oleoyl-rac-glycerol for targeted drug delivery (A VAN DIJCK, 2014).
- An Innovative Nanocarrier for Neuroprotection: Investigates the therapeutic benefits of encapsulating curcumin in stealth nanocarriers of DODAB and 1-oleoyl-rac-glycerol (MO) (1: 2) (T Soares, No Date Provided).
- Supporting Information Light-responsive Molecular Release from Cubosomes using Swell-Squeeze Lattice Control: Discusses molecular release mechanisms in structures containing 1-oleoyl-rac-glycerol (BE Jones et al., No Date Provided).
- The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study: Details the formulation of dry emulsion systems incorporating 1-oleoyl-rac-glycerol for improved pharmaceutical applications (M Pohlen, L Pirker, R Dreu, 2021).
- The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency: Includes an analysis of metabolic changes, noting the role of 1-oleoyl-rac-glycerol among other compounds (C Bocca et al., 2018).
Classe de stockage
10 - Combustible liquids
flash_point_f
309.2 °F - closed cup
flash_point_c
154.0 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
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Mona Basha et al.
International journal of pharmaceutics, 532(1), 478-490 (2017-09-20)
The current article highlights the application of spray drying technique to produce an ultra-fine powder encapsulating the antihyperlipidemic drug, atorvastatin calcium (ATV). First, ATV was dissolved in an emulsion formulation, and different carriers (pectin, alginate, chitosan HCl and hydroxypropylmethyl cellulose)
Monoolein: a magic lipid?
Kulkarni CV, et al.
Physical Chemistry Chemical Physics, 13(8), 3004-3021 (2011)
Nicholas J Wright et al.
Nature structural & molecular biology, 26(7), 599-606 (2019-06-27)
The human equilibrative nucleoside transporter 1 (hENT1), a member of the SLC29 family, plays crucial roles in adenosine signaling, cellular uptake of nucleoside for DNA and RNA synthesis, and nucleoside-derived anticancer and antiviral drug transport in humans. Because of its
Hyeun Wook Chang et al.
Bioorganic & medicinal chemistry letters, 18(12), 3589-3592 (2008-05-20)
Polyunsaturated fatty acid-derived monoglycerides were characterized from the marine brown alga Sargassum sagamianum, collected from Jeju Island, Korea. A new compound of this structural class was isolated and determined to be 1-octadecatetraenoyl glycerol, by combined spectroscopic methods. Based on the
Xiuhua You et al.
International journal of pharmaceutics, 471(1-2), 276-284 (2014-05-27)
Microemulsions show excellent potential as drug delivery systems, but the surfactants used to prepare them can cause side effects. Researchers have explored various strategies to expand microemulsion area and thereby reduce the surfactant content necessary, but how these strategies affect
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