739960
Resomer® RG 505, Poly(D,L-lactide-co-glycolide)
ester terminated, Mw 54,000-69,000
Synonyme(s) :
PLGA
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Formule linéaire :
[C3H4O2]x[C2H2O2]y
Numéro CAS:
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23
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form
amorphous
feed ratio
lactide:glycolide 50:50
mol wt
Mw 54,000-69,000
degradation timeframe
<3 months
viscosity
0.61-0.74 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)
transition temp
Tg 48-52 °C
storage temp.
2-8°C
SMILES string
O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O
InChI
1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2
InChI key
LCSKNASZPVZHEG-UHFFFAOYSA-N
General description
Poly(lactide-co-glycolide)(PLGA) is a biodegradable polymer used in the preparation of polymericmicrospheres. These polymers degrade in vivo by hydrolysis of their esterbackbone into non-toxic products, which are excreted by the kidneys oreliminated as CO2 and water through biochemical pathways. PLGAmicrospheres have been widely used to encapsulate drug molecules and have beenused as long-acting, sustained-release pharmaceutical formulations.
Application
Poly(lactide-co-glycolide)(PLGA) can be used to fabricate sustained-release drug delivery systems, for example, it can be used to encapsulate the anti-inflammatory lipophilic drug atorvastatin.
Legal Information
Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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