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870520P

Avanti

18:1 CDP DG

Avanti Research™ - A Croda Brand

Synonyme(s) :

1,2-dioleoyl-sn-glycero-3-(cytidine diphosphate) (ammonium salt)

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A propos de cet article

Formule empirique (notation de Hill) :
C48H91N5O15P2
Numéro CAS:
799812-77-4
Poids moléculaire :
1040.21
MDL number:
MFCD22416913
UNSPSC Code:
12352211
NACRES:
NA.25
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assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 25 mg (870520P-25mg), pkg of 1 × 5 mg (870520P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

phosphoglycerides
bioactive lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O1)([O-])=O)([O-])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+]

InChI

1S/C48H85N3O15P2.2H3N/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-43(52)61-37-40(64-44(53)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)38-62-67(57,58)66-68(59,60)63-39-41-45(54)46(55)47(65-41)51-36-35-42(49)50-48(51)56;;/h17-20,35-36,40-41,45-47,54-55H,3-16,21-34,37-39H2,1-2H3,(H,57,58)(H,59,60)(H2,49,50,56);2*1H3/b19-17-,20-18-;;/t40-,41-,45+,46?,47-;;/m1../s1

InChI key

NECNTGAHQCHVGS-BQGZBBTBSA-N

Application

18:1 CDP DG (1,2-dioleoyl-sn-glycero-3-(cytidine diphosphate)) may be used in preparation of liposomes.

Biochem/physiol Actions

18:1 CDP DG (1,2-dioleoyl-sn-glycero-3-(cytidine diphosphate)) is a diacylglycerol derivate. It acts as a substrate for phosphatidylserine synthase (Pss), an enzyme involved in the synthesis of phospholipids in various organisms. CDP-diacylglycerol serves as a precursor for the biosynthesis of phosphatidylinositides. Dysregulated CDP-diacylglycerol signaling pathway leads to depression.

Packaging

5 mL Clear Glass Sealed Ampule (870520P-25mg)
5 mL Clear Glass Sealed Ampule (870520P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Kimberly R Tyeryar et al.
BMC neuroscience, 9, 12-12 (2008-01-26)
Major depression is a serious mood disorder affecting millions of adults and children worldwide. While the etiopathology of depression remains obscure, antidepressant medications increase synaptic levels of monoamine neurotransmitters in brain regions associated with the disease. Monoamine transmitters activate multiple
Ru-Yin Huang et al.
Current microbiology, 77(5), 710-715 (2020-01-04)
Phosphatidylserine synthase (Pss) is involved in the metabolic pathway in phospholipid synthesis in different organisms. In this study, Pss expression in Vibrio parahaemolyticus was verified through liquid chromatography tandem-mass spectrometry. To analyze the characteristics of Pss, the recombinant Pss was
Andrew G Reidenbach et al.
Cell chemical biology, 25(2), 154-165 (2017-12-05)
Human COQ8A (ADCK3) and Saccharomyces cerevisiae Coq8p (collectively COQ8) are UbiB family proteins essential for mitochondrial coenzyme Q (CoQ) biosynthesis. However, the biochemical activity of COQ8 and its direct role in CoQ production remain unclear, in part due to lack