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18:1 PEG5000 PE, Avanti Research™ - A Croda Brand 880230P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 2 × 100 mg (880230P-200mg), pkg of 1 × 25 mg (880230P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 880230P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113OCH3])=O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]
Application
18:1 PEG5000 PE or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000 may be used in lipid bilayer preparation, and DOX free base loaded mixed dendrimer micelles (MDM DOX) preparation for tumor targeted delivery of siRNA and drugs.
Biochem/physiol Actions
18:1 PEG5000 PE, also referred as 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] (PEG5k-DOPE) in combination with lipid modified dendrimer copolymer supports co-delivery of siRNA and drugs to tumors.
Packaging
5 mL Clear Glass Sealed Ampule (880230P-25mg)
5 mL Clear Glass Sealed Ampule (880230P-200mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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TCR--pMHC bond conformation controls TCR ligand discrimination
Sasmal DK, et al.
Cellular & Molecular Immunology (2019)
Dibyendu K Sasmal et al.
Cellular & molecular immunology, 17(3), 203-217 (2019-09-19)
A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR-pMHC bonds and the conformations of
Jiayi Pan et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 136, 18-28 (2019-01-12)
Multidrug resistance (MDR) significantly decreases the therapeutic efficiency of anti-cancer drugs. Its reversal could serve as a potential method to restore the chemotherapeutic efficiency. Downregulation of MDR-related proteins with a small interfering RNA (siRNA) is a promising way to reverse